Models#

list_models

List all available models.

Vision models#

CHIEF

GitHub Paper Params: 27.5M 768 features AGPL-3.0 [Wang et al., 2024] Clinical Histopathology Imaging Evaluation Foundation (CHIEF)

CONCHVision

🤗Hugging Face GitHub Paper Params: 395.2M 512 features CC-BY-NC-ND-4.0 [Lu et al., 2024] CONtrastive learning from Captions for Histopathology (CONCH)

CTransPath

GitHub Paper Params: 27.5M 768 features GPL-3.0 [Wang et al., 2022] Transformer-based unsupervised contrastive learning for histopathological image classification

GigaPath

🤗Hugging Face GitHub Paper Params: 1.13B 1536 features Apache 2.0 with conditions [Xu et al., 2024] A whole-slide foundation model for digital pathology

H0Mini

🤗Hugging Face GitHub Paper Params: 85.7M 1536 features CC-BY-NC-ND-4.0 [Filiot et al., 2025] A distilled version of H-optimus-0

HOptimus0

🤗Hugging Face GitHub Params: 1.13B 1536 features Apache 2.0 [Saillard et al., 2024] Vision foundation model

HOptimus1

🤗Hugging Face GitHub Params: 1.13B 1536 features CC-BY-NC-ND-4.0 [Bioptimus, 2025] Vision foundation model

HibouB

🤗Hugging Face GitHub Paper Params: 85.7M 768 features Apache 2.0 [Nechaev et al., 2024] A family of foundational vision transformers for pathology

HibouL

🤗Hugging Face GitHub Paper Params: 303.7M 1024 features Apache 2.0 [Nechaev et al., 2024] A family of foundational vision transformers for pathology

Midnight

🤗Hugging Face GitHub Paper Params: 1.14B 3072 features MIT [Karasikov et al., 2025] Training state-of-the-art pathology foundation models with orders of magnitude less data

PLIPVision

🤗Hugging Face GitHub Paper Params: 87.8M 512 features Non-commercial [Huang et al., 2023] Pathology Language-Image Pretraining (PLIP)

Phikon

🤗Hugging Face GitHub Paper Params: 85.8M 768 features Owkin non-commercial license [Filiot et al., 2023] Scaling self-Supervised Learning for histopathology with Masked Image Modeling

PhikonV2

🤗Hugging Face GitHub Paper Params: 303.4M 1024 features Owkin non-commercial license [Filiot et al., 2024] A large and public feature extractor for biomarker prediction

UNI

🤗Hugging Face GitHub Paper Params: 303.4M 1024 features CC-BY-NC-ND-4.0 [Chen et al., 2024] General-purpose self-supervised model for pathology

UNI2

🤗Hugging Face GitHub Paper Params: 681.4M 1536 features CC-BY-NC-ND-4.0 [Chen et al., 2024] An improved version of UNI

Virchow

🤗Hugging Face Paper Params: 631.2M 2560 features Apache 2.0 [Vorontsov et al., 2024] A foundation model for clinical-grade computational pathology and rare cancers detection

Virchow2

🤗Hugging Face Paper Params: 631.2M 2560 features CC-BY-NC-ND-4.0 [Zimmermann et al., 2024] Scaling self-supervised mixed magnification models in pathology

Multimodal models#

CONCH

🤗Hugging Face GitHub Paper Params: 395.2M 512 features CC-BY-NC-ND-4.0 [Lu et al., 2024] CONtrastive learning from Captions for Histopathology (CONCH)

OmiCLIP

🤗Hugging Face GitHub Paper Params: 638.5M BSD-3-Clause [Chen et al., 2025] A visual-omics foundation model to bridge histopathology with spatial transcriptomics

PLIP

🤗Hugging Face GitHub Paper Params: 87.8M 512 features Non-commercial [Huang et al., 2023] Pathology Language-Image Pretraining (PLIP)

Prism

🤗Hugging Face Paper Params: 557.7M CC-BY-NC-ND-4.0 [Shaikovski et al., 2024] A multi-modal generative foundation model for slide-level histopathology, the Prism models encode slide-level embeddings from Virchow.

Titan

🤗Hugging Face GitHub Paper Params: 158.9M 768 features CC-BY-NC-ND-4.0 [Ding et al., 2024] Multimodal whole slide foundation model for pathology

Segmentation models#

Cellpose

🤗Hugging Face GitHub Paper BSD-3-Clause [Stringer et al., 2021] Cell segmentation model

GrandQCArtifact

GitHub Paper Params: 6.3M CC-BY-NC-SA-4.0 [Weng et al., 2024] Artifact segmentation model from GrandQC

GrandQCTissue

GitHub Paper Params: 6.6M CC-BY-NC-SA-4.0 [Weng et al., 2024] Tissue segmentation model from GrandQC

Instanseg

Apply the InstaSeg model to the input image.:octicon:check-circle-fill;1em;sd-text-success; GitHub Paper Params: 3.8M Apache 2.0 [Goldsborough et al., 2024] An embedding-based instance segmentation algorithm optimized for accurate, efficient and portable cell segmentation.

NuLite

GitHub Paper Params: 47.9M Apache 2.0; CC-BY-NC-SA-4.0 [Tommasino et al., 2024] Nuclei instance segmentation and classification

PathProfilerTissueSegmentation

Tissue segmentation model from PathProfiler.

SAM

GitHub Paper Apache 2.0 SAM model for image segmentation

SMPBase

This is a base class for any models from segmentation models pytorch

Tile prediction models#

FocusLiteNN

GitHub Paper Params: 299 Prosperity Public License 3.0.0 [Wang et al., 2020] High efficiency Focus Quality Assessment for digital pathology

PathProfilerQC

GitHub Paper Params: 11.2M GPL-3.0 [Haghighat et al., 2022] Quality assessment of histology images

SpiderBreast

🤗Hugging Face Params: 303.9M CC BY-NC 4.0 Tile classification for breast

SpiderColorectal

🤗Hugging Face Params: 303.9M CC BY-NC 4.0 Tile classification for colorectal

SpiderSkin

🤗Hugging Face Params: 303.9M CC BY-NC 4.0 Tile classification for skin

SpiderThorax

🤗Hugging Face Params: 303.9M CC BY-NC 4.0 Tile classification for thorax

Slide encoder models#

multimodal.Prism

🤗Hugging Face Paper Params: 557.7M CC-BY-NC-ND-4.0 [Shaikovski et al., 2024] A multi-modal generative foundation model for slide-level histopathology, the Prism models encode slide-level embeddings from Virchow.

multimodal.Titan

🤗Hugging Face GitHub Paper Params: 158.9M 768 features CC-BY-NC-ND-4.0 [Ding et al., 2024] Multimodal whole slide foundation model for pathology

vision.CHIEFSlideEncoder

GitHub Paper Params: 1.2M AGPL-3.0 [Wang et al., 2024] Clinical Histopathology Imaging Evaluation Foundation (CHIEF)

vision.GigaPathSlideEncoder

🤗Hugging Face GitHub Paper Apache 2.0 with conditions [Xu et al., 2024] A whole-slide foundation model for digital pathology

vision.MadeleineSlideEncoder

🤗Hugging Face GitHub Paper Params: 3.2M CC BY-NC-ND 4.0 [Jaume et al., 2024] Multistain Pretraining for Slide Representation Learning in Pathology

Computer vision features#

Brightness

Calculate the brightness of a tile.

Canny

Calculate the canny edge detection score of a tile.

Contrast

Calculate the contrast of a tile.

Entropy

Calculate the entropy of a tile.

HaralickTexture

Calculate texture features using Gray Level Co-occurrence Matrix (GLCM).

Saturation

Calculate the color saturation of a tile.

Sharpness

Calculate the sharpness of a tile.

Sobel

Calculate the sobel of a tile.

SplitRGB

Calculate the RGB value of a tile.

Base model class#